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Abstract #3466

Characterizing Brain Tumor Microstructure with SANDI using 300 mT/m Gradients

Ying-Hua Chu1, Yifan Yuan2, Yi-Cheng Hsu1, Shuhao Mei2, Wenwen Yu3, He Wang3, and Qi Yue2
1MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China, 2Huashan Hospital, Fudan University, Shanghai, China, 3Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Keywords: Microstructure, Microstructure

Motivation: Precisely locating tumor regions is challenging for effective surgery and radiotherapy.

Goal(s): Enhance tumorous area identification accuracy.

Approach: We integrated SANDI to model both stick and spherical cell types, estimating their densities. We introduced a metric quantifying spherical cell ratio relative to total cell volume for characterizing elevated tumor cell density.

Results: Our model effectively characterizes microstructural variations in brain tumor areas. The newly proposed cell number density ratio parameter provides a distinctive marker, highlighting high cell density within tumors. This approach holds promise for improving tumor localization, treatment planning, and patient outcomes.

Impact: Brain tumor microstructure characterization using SANDI showed microstructure changes in tumors and edema. The introduced metric, sensitive to tumor changes, holds promise for early invasion detection, enhancing diagnostic precision.

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