(ISMRM 2024) TENEXI: Echo time-dependent neurite exchange imaging for in vivo evaluation of exchange time and relaxation time on the Connectome 2.0 scanner
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Abstract #3468

TENEXI: Echo time-dependent neurite exchange imaging for in vivo evaluation of exchange time and relaxation time on the Connectome 2.0 scanner

Hong-Hsi Lee1, Kwok Shing Chan1, Gabriel Ramos Llorden1, and Susie Y Huang1
1Radiology, Massachusetts General Hospital, Charlestown, MA, United States

Synopsis

Keywords: Microstructure, Gray Matter, Exchange, relaxation, diffusion, time dependence

Motivation: It is challenging to evaluate both T2 relaxation time and exchange time in intra-neurite and extra-cellular spaces of in vivo gray matter.

Goal(s): To evaluate neurite exchange time and compartmental T2 relaxation times using a relaxation-diffusion-exchange protocol on Connectome 2.0.

Approach: We acquired in vivo time-dependent diffusion-relaxation MRI data with multiple diffusion times (13-30ms) and echo times (31-120ms) using the Connectome 2.0 scanner with high-performance gradient system.

Results: The exchange time and intra-neurite/extra-cellular relaxation times are about 10 ms and 120/80 ms across the cortical ribbon, respectively.

Impact: In vivo mapping of water exchange and compartmental relaxation times is achievable in the brain gray matter using the high gradient performance Connectome 2.0 scanner. Multi-contrast MR protocol helps to improve the accuracy and precision in model fitting.

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Keywords