Abstract #3472

Evaluating cortical soma radius and intra-soma and neurite fractions using ultra-high-gradient diffusion MRI data acquired at 500 mT/m

Hansol Lee¹, Yixin Ma¹, Gabriel Ramos-Llordén¹, Kwok-Shing Chan¹, Eva A. Krijnen^2,3, Mirsad Mahmutovic⁴, Boris Keil^4,5, Eric C. Klawiter², Hong-Hsi Lee¹, and Susie Y. Huang¹

¹Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ³MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands, ⁴Institute of Medical Physics and Radiation Protection, Mittelhessen University of Applied Sciences, Giessen, Germany, ⁵Department of Diagnostic and Interventional Radiology, University Hospital Marburg, Philipps University of Marburg, Marburg, Germany

Synopsis

Keywords: Gray Matter, Diffusion/other diffusion imaging techniques, Gray matter, High-performance gradient system

Motivation: The Connectome 2.0 MRI scanner equipped with 500 mT/m gradient strength and 600 T/m/s slew rate is expected to advance gray matter microstructural characterization within the living human brain.

Goal(s): To compare Soma And Neurite Density imaging (SANDI) metrics obtained from Connectome 2.0 and 1.0.

Approach: We applied SANDI model fitting to diffusion MRI data acquired from 10 healthy subjects scanned on the Connectome 2.0 and 1.0 scanners.

Results: We observed lower soma radius throughout the cortex on Connectome 2.0 compared to Connectome 1.0. SANDI metrics from Connectome 2.0 exhibited considerable contrast within the sensorimotor cortex that wasn’t apparent on Connectome 1.0.

Impact: The Connectome 2.0 MRI scanner with 500 mT/m gradients advances non-invasive characterization of gray matter microstructure in the living human brain and enables mapping of real differences in cyto- and myeloarchitecture with greater sensitivity compared to the original Connectome scanner.

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