Keywords: Diffusion Modeling, Microstructure, Multicenter study, multicenter phantom study, multicenter stability assessment of Bingham-NODDI model, Bingham-NODDI model, NODDI model
Motivation: The NODDI model has been proven to be a powerful tool, however it struggles to depict complex brain neurite structures.
Goal(s): The Bingham-NODDI model offers a more detailed approach for capturing pathological-related brain changes, although its validation is still ongoing. This study aims to make progress in this direction.
Approach: To assess the Bingham-NODDI model's reliability across different MRI scanner systems, this study uses a consistent acquisition protocol, fostering the model's robustness.
Results: The outcomes confirm Bingham-NODDI model’s reliability, promising potential clinical applications. By enhancing generalizability and validation, this research clears the path for improved diagnostic and research tools in neuroscience.
Impact: The Bingham-NODDI model offers valuable insights into brain microstructure changes. Its integration into clinical practice alongside medical teams and neuroscientists is highly promising. This multi-center study advances this goal by assessing model stability, fostering future collaborations between scientistis and clinicians.
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