Abstract #3488

Time-dependent diffusion MRI could distinguish between functioning and non-functioning pituitary adenoma

Kiyohisa Kamimura¹, Tsubasa Nakano^1,2, Tomohito Hasegawa², Masanori Nakajo², Shingo Fujio³, Takashi Iwanaga⁴, Hiroshi Imai⁵, Thorsten Feiweier⁶, and Takashi Yoshiura^2,7

¹Department of Advanced Radiological Imaging, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ³Neurosurgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ⁴Radiological Technology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ⁵Siemens Healthcare K.K., Tokyo, Japan, ⁶Siemens Healthcare GmbH, Erlangen, Germany, ⁷Advanced Radiological Imaging, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniques

Motivation: Differentiation between functioning and non-functioning pituitary adenoma (PA) is clinically relevant. Feasibility of their microstructural differentiation is undetermined.

Goal(s): To investigate whether the time-dependent diffusion MRI can distinguish functioning from non-functioning PA.

Approach: Twenty-four patients with functioning and 30 with non-functioning PA were examined. Pituitary DWI was performed using inner FOV EPI based on 2D-selective radiofrequency excitations with oscillating (diffusion time=7.1ms) and pulsed (36.3ms) gradient preparations. ADC change (cADC) and relative ADC change (rcADC) between two diffusion-times were calculated.

Results: cADC was significantly higher in functioning than in non-functioning PAs (P=0.012), showing that time-dependent diffusion MRI can distinguish them.

Impact: Our results clarified that there are microstructural differences between functional and non-functional pituitary adenomas. Time-dependent diffusion MRI of the pituitary gland can detect their microstructural characteristics, providing clues as to their imaging differentiation.

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