Abstract #3496

Nonparametric evaluation of diffusion regimes in brain tumours and associated diffusion hyperintensities

Ana-Maria Oros-Peusquens*¹, Ricardo Louçao*², and N. Jon Shah^1,3,4,5

¹INM-4, Research Centre Juelich, Juelich, Germany, ²Centre of Neurosurgery, University Hospital of Cologne, Cologne, Germany, ³RWTH Aachen University, Aachen, Germany, ⁴INM-11, JARA, Research Centre Juelich, Juelich, Germany, ⁵JARA - BRAIN - Translational Medicine, Aachen, Germany

Synopsis

Keywords: Microstructure, Microstructure

Motivation: To investigate tumour-associated diffusion hyperintensities

Goal(s): Might provide some insight into tumour environment leading to restricted diffusion.

Approach: Extended diffusion range, with b-values from 0 to 10000 and two echo times, allowing for NNLS decomposition of diffusion spectra and T2 mapping.

Results: Restricted diffusion characterised.

Impact: Possibly relevant to tumour cell migration and associated changes in the extracellular matrix.

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