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Abstract #3512

Magnetic Resonance Elastography to Identify Prostate Phenotypes of Lower Urinary Tract Symptoms

Shane A. Wells1, Cody J. Johnson2, Juan-Pablo Gonzalez-Pereira3, William A. Ricke3, Matthew Grimes3, Timothy J. Hall3, Yun Jiang4, Vikas Gulani4, Alejandro Roldan-Alzate3, and Christopher L. Brace3
1Radiology, Urology, University of Michigan, Ann Arbor, MI, United States, 2University of Wisconsin School of Medicine and Publich Health, Madison, WI, United States, 3University of Wisconsin, Madison, WI, United States, 4University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Prostate, Elastography, MRE, Lower Urinary Tract Symptoms, Shear Stiffness, LUTS

Motivation: There is a critical need for significant improvements in image-based assessment of the prostate in men with lower urinary tract symptoms (LUTS).

Goal(s): To develop non-invasive image-based biomarkers that will optimize clinical management of men with LUTS.

Approach: Quantify transition zone complex shear modulus (henceforth ‘stiffness’) with transperineal magnetic resonance elastography (pMRE) at 90Hz and 100Hz.

Results: Mean periurethral TZ stiffness increases with frequency (3.0clip_image006.png">0.4kPa).

Impact: Transperineal pMRE is technically feasible, generates volumetric whole prostate quantitative parametric maps that can differentiate zonal prostate anatomy. Periurethral TZ stiffness, measured with pMRE, may be a clinically useful biomarker for identifying discrete phenotypes of LUTS.

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Keywords

prostate