Abstract #3512

Magnetic Resonance Elastography to Identify Prostate Phenotypes of Lower Urinary Tract Symptoms

Shane A. Wells¹, Cody J. Johnson², Juan-Pablo Gonzalez-Pereira³, William A. Ricke³, Matthew Grimes³, Timothy J. Hall³, Yun Jiang⁴, Vikas Gulani⁴, Alejandro Roldan-Alzate³, and Christopher L. Brace³

¹Radiology, Urology, University of Michigan, Ann Arbor, MI, United States, ²University of Wisconsin School of Medicine and Publich Health, Madison, WI, United States, ³University of Wisconsin, Madison, WI, United States, ⁴University of Michigan, Ann Arbor, MI, United States

Synopsis

Keywords: Prostate, Elastography, MRE, Lower Urinary Tract Symptoms, Shear Stiffness, LUTS

Motivation: There is a critical need for significant improvements in image-based assessment of the prostate in men with lower urinary tract symptoms (LUTS).

Goal(s): To develop non-invasive image-based biomarkers that will optimize clinical management of men with LUTS.

Approach: Quantify transition zone complex shear modulus (henceforth ‘stiffness’) with transperineal magnetic resonance elastography (pMRE) at 90Hz and 100Hz.

Results: Mean periurethral TZ stiffness increases with frequency (3.0clip_image006.png">0.4kPa).

Impact: Transperineal pMRE is technically feasible, generates volumetric whole prostate quantitative parametric maps that can differentiate zonal prostate anatomy. Periurethral TZ stiffness, measured with pMRE, may be a clinically useful biomarker for identifying discrete phenotypes of LUTS.

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