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Abstract #3515

Development of a Whole Abdominopelvic Variable Resolution Hyperpolarized 13C MRI Approach for Advanced Prostate Cancer Clinical Research

Tanner M. Nickles1,2, Hsin-Yu Chen1, Yaewon Kim1, Philip M. Lee1,2, Daniel T. Gebrezgiabhier1,2, Robert A. Bok1, Ivan de Kouchkovsky3, Michael A. Ohliger1, Zhen J. Wang1, Peder E. Z. Larson1,2, John Kurhanewicz1,2, Rahul Aggarwal3, Jeremy W. Gordon1,2, and Daniel B. Vigneron1,2
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Bioengineering Joint PhD Program, UC Berkeley-UCSF, San Francisco, CA, United States, 3Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Prostate, Prostate, Cancer, Hyperpolarized MR

Motivation: Monitoring the progression or response of advanced prostate metastases is a current clinical unmet need that is not reliably delineated with current CT and PET.

Goal(s): Here, we developed a high-resolution whole abdominopelvic [1-13C]pyruvate HP MRI approach for the metabolic biomarker characterization of metastases in prostate cancer patients.

Approach: A variable-resolution imaging approach was used to provide high-resolution [1-13C]pyruvate, robust spatiotemporal denoising and B1+ variation correction methods were used to quantify the rate-constant for the conversion of [1-13C]pyruvate to lactate, kPL.

Results: Improved conspicuity of [1-13C]pyruvate distribution and kPL conversion maps of metastatic lesions were achieved with the new approach.

Impact: The improvement in [1-13C]pyruvate resolution and clear delineation of highly metabolically active metastatic lesions in kPL maps demonstrated the potential of [1-13C]pyruvate HP MRI in advanced prostate cancer.

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Abstract

Keywords