(ISMRM 2024) Towards Sequence Optimization for Multi-Compartment Magnetic Resonance Fingerprinting
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Abstract #3547

Towards Sequence Optimization for Multi-Compartment Magnetic Resonance Fingerprinting

Tom Griesler1,2,3, Maximilian Gram1,4, Jannik Stebani1, Petra Albertova1,4, Peter Dawood1, Nicole Seiberlich2,3, Peter Michael Jakob1, and Martin Blaimer5
1Experimental Physics 5, University of Würzburg, Würzburg, Germany, 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 3Department of Radiology, University of Michigan, Ann Arbor, MI, United States, 4Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, 5Magnetic Resonance and X-Ray Imaging Department, Division Development Center X-Ray Technology, Fraunhofer Institute for Integrated Circuits IIS, Würzburg, Germany

Synopsis

Keywords: MR Fingerprinting, MR Fingerprinting, Myelin

Motivation: Volumetric measurements of the myelin water fraction in the human brain are hampered by long acquisition times.

Goal(s): Investigate the extent to which sequence optimization can improve the encoding efficiency of multi-compartment Magnetic Resonance Fingerprinting.

Approach: Implement different cost functions to optimize MRF sequence parameters. Validate the results with simulations, one-dimensional projection measurements in phantoms and in vivo measurements.

Results: MRF sequence design has a significant influence on partial volume estimation with MRF. Optimization can yield improved tissue discrimination and more detailed myelin water fraction maps.

Impact: MRF sequence design has a significant influence on partial volume estimation, yielding potential for optimization of, for example, tissue discrimination and myelin water fraction mapping. Further investigation of cost functions and validation of results is needed.

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Keywords

optimizationfingerprintingfractionmyelintissuewatervolume