Abstract #3550

Feasibility of Knee MR Fingerprinting at 0.55T and comparison with 3.0T MAPSS: Hip-OA cohort with probable early knee cartilage-loss

Rupsa Bhattacharjee¹, Xiaozhi Cao^2,3, Congyu Liao^2,3, Zheren Zhu¹, Zhitao Li², Sharmila Majumdar¹, Kawin Setsompop^2,3, and Yang Yang¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States, ³Department of Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

Keywords: MR Fingerprinting, Low-Field MRI

Motivation: Low-cost 0.55T-scanners pose an excellent opportunity to formulate efficient, fast, and quantitative T₂ mapping methods that could enhance the reach of early OA-diagnosis.

Goal(s): To analyze the feasibility of a novel, fast, and high-resolution MRF-scanning technique to quantify knee cartilage-T₂ overcoming the low SNR and inefficient gradient systems at 0.55T and compare against the MAPSS approach at 3.0T.

Approach: A suite of techniques was leveraged for MRF, including an optimized-sampling-trajectory, subspace-reconstruction, locally-low-rank-constraint, gradient-waveform-correction, Cramer-Rao-Lower-Bound (CRLB)-optimization for flip-angle-patterns, motion-correction, and deep-learning-based-denoising.

Results: The average T₂ increase at 0.55T compared to 3.0T provides a wider range for the depiction of granular regions of elevated cartilage-T₂

Impact: In this study, advanced techniques including CRLB-optimization, gradient trajectory correction, subspace reconstruction, attention-based denoising, and motion correction were included to demonstrate the feasibility and benefits of a faster, higher-resolution Knee MRF acquisition on a cost-effective 0.55T scanner compare with 3.0T MAPSS.

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