Keywords: Tumors (Pre-Treatment), Tumor, Brain, Glioma, CEST&MT
Motivation: ATRX gene mutation is correlated with better prognosis in IDH1-mutant lower-grade gliomas (LrGGs).
Goal(s): We aimed to investigate the predictability of ATRX mutation status using multipool CEST MRI.
Approach: The CEST Z-spectrum was fitted with 5 Lorentzian functions. We compared the differences in 5 metrics between ATRX mutant and wild-type gliomas. And ROC analyses were performed to evaluate predictive performances of metrics.
Results: ATRX mutant IDH1-mutant LrGGs showed significantly decreased direct saturated water (DS), semi-solid magnetization transfer (MT) signals and increased amine signal compared to ATRX wild-type group. The combination of metrics yielded the highest AUC of 0.773.
Impact: Multipool CEST MRI demonstrated good ability to distinguish ATRX mutant gliomas from wild-type gliomas, it may be as a useful imaging biomarker for precise prediction of ATRX mutation status and facilitate the diagnosis and prognosis of glioma patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords