Abstract #3581

Triexponential multi-b-value diffusion-weighted imaging metrics may detect WHO grade and key molecular markers in glioma patients

Zhengyang Zhu¹, Jianan Zhou¹, Zengping Lin², Jianmin Yuan², Huiquan Yang¹, Chuanshuai Tian¹, Xin Zhang¹, and Bing Zhang¹

¹Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai, China, Shanghai, China

Synopsis

Keywords: Tumors (Pre-Treatment), Brain, Ki67, IDH, Glioma

Motivation: WHO grade, Ki67 and IDH mutation are important for management and prognosis evaluation in glioma patients.

Goal(s): To investigate the value of Tri-exponential model (TEM) in preidcting WHO grade, Ki67 and IDH mutation of gliomas

Approach: 12 b-value DWI were obtained from glioma patients, TEM, SEM and IVIM model were analyzed for each patient. Univariate and Multivariate Logistic Regression were utilized to construct prediction model.

Results: TEM model achieved highest AUC on WHO Grade prediction task, while IVIM performed better on Ki67 and IDH mutation prediction task.

Impact: This study illustrated the potential of applying TEM model on predicting WHO grade Ki67 and IDH mutation in adult diffuse gliomas.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.