Abstract #3591

A fast, vendor-neutral protocol for multi-center, multi-parametric quantitative MRI studies in brain tumor patients

Dennis C. Thomas^1,2,3,4, Ralf Deichmann⁵, Ulrike Nöth⁵, Christian Langkammer⁶, Mónica Ferreira⁷, Elke Hattingen^1,2,3,4, and Katharina J. Wenger^1,2,3,4

¹Institute of Neuroradiology, Goethe University Frankfurt, University Hospital Frankfurt, Frankfurt, Germany, ²University Cancer Center Frankfurt (UCT), Frankfurt am Main, Germany, ³Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany, ⁴German Cancer Research Center (DKFZ) Heidelberg and German Cancer Consortium (DKTK), Heidelberg, Germany, ⁵Brain Imaging Center, Frankfurt, Germany, ⁶Department of Neurology, Medical University of Graz, Graz, Austria, ⁷German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

Synopsis

Keywords: Tumors (Pre-Treatment), Quantitative Imaging, Multi-parametric Quantitative MRI

Motivation: Multi-centric multi-parametric quantitative MRI (mp-qMRI) studies require short and vendor-neutral protocols.

Goal(s): The goal was to develop and validate an 8-minute, vendor-neutral protocol for multi-center mp-qMRI studies on brain tumor patients at 3T.

Approach: 5 Volunteers were measured at two scanners. Application of the proposed method was demonstrated for one brain metastasis patient, where artefact free qMRI maps were obtained.

Results: qMRI maps (T1, T2*, PD and QSM) obtained from 5 volunteers on two scanners showed a very good reproducibility. Among the parameters, PD yielded the lowest COV. Artefact free qMRI maps are demonstrated in a brain metastasis patient.

Impact: We propose an 8-minute, vendor-neutral mp-qMRI protocol for 3T studies in brain tumor patients. T1, T2*, PD and QSM maps are demonstrated in 5 healthy volunteers and one brain metastsis patient. Multi-centric qMRI studies could use this fast mp-qMRI protocol.

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