Abstract #3593

Low-dose Dynamic Imaging for Cerebrovascular Evaluation (LD-DICE)

Yang Chen^1,2, Jiayu Xiao², Anthony G. Christodoulou³, Debiao Li⁴, Frances Chow⁵, Gabriel Zada⁶, Eric Chang⁷, Mark Shiroishi², and Zhaoyang Fan^1,2

¹Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ³Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁵Department of Neuro-oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁶Department of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ⁷Department of Radiation Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Tumors (Post-Treatment), DSC & DCE Perfusion, Low dose

Motivation: Gadolinium retention in the human body following dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI remains a health concern to many patients, especially those who need long-term imaging follow-up.

Goal(s): This work aims to investigate the feasibility of using a recently developed technique, MR multitasking-based dynamic imaging for cerebrovascular evaluation (DICE), to quantify permeability and perfusion with a 0.03 mmol/kg dose.

Approach: Numerical simulations were conducted to determine the optimal dose level. Assessments for the agreement of low-dose DICE (LD-DICE) with full-dose DICE (FD-DICE) were performed.

Results: Good correlation was achieved. Brain tissue perfusion and permeability can be quantified simultaneously with LD-DICE.

Impact: Low-dose DICE will allow for comprehensive tumor vascularity evaluation with considerably less contrast agent than clinical standard protocols, which will benefit brain tumor patients who need frequent imaging follow-ups.

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