Meeting Banner
Abstract #3614

Prediction of intra-tumoural tertiary lymphoid structures in intrahepatic cholangiocarcinoma using MRI-based radiomics

Ying Xu1, Yi Yang2, Feng Ye1, Lizhi Xie3, Sicong Wang3, and Xinming Zhao4
1Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3Magnetic Resonance Imaging Research, General Electric Healthcare, Beijing, China, Beijing, China, 4Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Diagnosis/Prediction, Biliary, Biomarkers; Intrahepatic cholangiocarcinoma; Magnetic resonance imaging; Tertiary lymphoid structures; Radiomics

Motivation: Tertiary lymphoid structures (TLSs) can only be assessed by postoperative specimen and a non-invasive tool to preoperatively evaluate TLSs is still lacking.

Goal(s): To explore the association between TLSs status of patients with ICC and preoperative magnetic resonance imaging (MRI) radiomics analysis.

Approach: Radiomics features were subjected to LASSO regression to select the most associated features of TLSs and construct the radiomics model.

Results: The AUCs of Rad-score were 0.85, 0.81, and 0.84 in the T, V1, and V2 cohorts, respectively. Low-risk group showed significantly better median RFS than that of the high-risk group, which was also confirmed in cohort V1 and V2.

Impact: TLSs have been reported to have prognostic value and guiding significance to immunotherapy in ICC patients. The MRI radiomics signature could serve as a non-invasive tool to preoperatively predict intra-tumoural TLSs status of ICC patients and correlate significantly with prognosis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords