Abstract #3614

Prediction of intra-tumoural tertiary lymphoid structures in intrahepatic cholangiocarcinoma using MRI-based radiomics

Ying Xu¹, Yi Yang², Feng Ye¹, Lizhi Xie³, Sicong Wang³, and Xinming Zhao⁴

¹Department of Diagnostic Radiology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ³Magnetic Resonance Imaging Research, General Electric Healthcare, Beijing, China, Beijing, China, ⁴Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Diagnosis/Prediction, Biliary, Biomarkers; Intrahepatic cholangiocarcinoma; Magnetic resonance imaging; Tertiary lymphoid structures; Radiomics

Motivation: Tertiary lymphoid structures (TLSs) can only be assessed by postoperative specimen and a non-invasive tool to preoperatively evaluate TLSs is still lacking.

Goal(s): To explore the association between TLSs status of patients with ICC and preoperative magnetic resonance imaging (MRI) radiomics analysis.

Approach: Radiomics features were subjected to LASSO regression to select the most associated features of TLSs and construct the radiomics model.

Results: The AUCs of Rad-score were 0.85, 0.81, and 0.84 in the T, V1, and V2 cohorts, respectively. Low-risk group showed significantly better median RFS than that of the high-risk group, which was also confirmed in cohort V1 and V2.

Impact: TLSs have been reported to have prognostic value and guiding significance to immunotherapy in ICC patients. The MRI radiomics signature could serve as a non-invasive tool to preoperatively predict intra-tumoural TLSs status of ICC patients and correlate significantly with prognosis.

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