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Abstract #3666

Quantification of 1H-MRSI metabolites in mild traumatic brain injury using relaxation correction from MRF

Anna M Chen1,2,3, Andrea Klein1,2, Teresa Gerhalter1,2, Martin Gajdošík1,2, Seena Dehkharghani1,2,4, Rosemary Peralta1,2, Mia Gajdošík1,2, Mickael Tordjman1,2,5, Sulaiman Sheriff6, Sinyeob Ahn7, Tamara Bushnik8, Alejandro Zarate8, Jonathan M Silver9, Brian S Im8, Stephen P Wall10, Guillaume Madelin1,2,3, and Ivan I Kirov1,2,3,4
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 3Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, 4Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, 5Department of Radiology, Hôpital Cochin, Paris, France, 6Department of Radiology, University of Miami Miller School of Medicine, Miami, FL, United States, 7Siemens Medical Solutions USA Inc., Malvern, PA, United States, 8Department of Rehabilitation Medicine, New York University Grossman School of Medicine, New York, NY, United States, 9Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, 10Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Multi-Contrast, Spectroscopy, White Matter, MR Fingerprinting, Relaxometry

Motivation: Accurate 1H-MRS metabolite quantification requires adjustments for metabolite and water signal relaxation, which are challenging to measure.

Goal(s): Our goal was to examine whether an MRF-based correction of subject-specific water relaxation times, applied to patients with mild traumatic brain injury (mTBI), yields results and effect sizes comparable with a conventional literature-based correction approach that utilizes one set of relaxation times for all subjects.

Approach: MRF and 1H-MRSI were acquired in 21 mTBI patients and 20 age-matched controls for quantification of metabolite concentrations in six white matter regions.

Results: Both methods yielded similar findings with comparable effect sizes across all metabolites in all regions.

Impact: In the context of intermediate TR and short TE, the standard absolute quantification method based on one literature-derived set of water relaxation times for all subjects may be appropriate for studying white matter metabolism in mild traumatic brain injury.

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Abstract

Keywords