Abstract #3700

Determining grade and subtype of meningiomas with inversion recovery multiple overlapping-echo detachment imaging

Yijie Yang¹, Qizhi Yang¹, Jianfeng Bao², Zhigang Wu³, Liangjie Lin³, Jiazheng Wang³, Jianhui Zhong⁴, Congbo Cai¹, and Shuhui Cai¹

¹Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China, ²Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³Clinical & Technical Support, Philips Healthcare, shenzhen, China, ⁴Department of Imaging Sciences, University of Rochester, New York, NY, United States

Synopsis

Keywords: Tumors (Pre-Treatment), Tumor, T2 mapping with FLAIR

Motivation: T2 mapping with FLAIR eliminates the interference of cerebrospinal fluid, depicting lesion more precise than conventional T2 mapping, but its use for grading and classifying meningiomas is scarce.

Goal(s): To investigate the value of a single-shot T2-FLAIR mapping method, inversion recovery multiple overlapping-echo detachment imaging (IR-MOLED), in distinguishing grades and subtypes of meningiomas.

Approach: IR-MOLED was applied on meningioma patients (N = 45), and histogram analysis of enhanced tumor regions was performed based on the resultant parametric maps.

Results: T2-FLAIR mapping is sensitive in determining the meningiomas grade (AUC = 0.813) and subtype (AUC = 0.971).

Impact: IR-MOLED-based quantitative analysis is promising in differentiating high and low grades and subtypes of meningiomas, especially in patients losing body control.

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