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Abstract #3715

Simultaneous brain susceptibility, T1 and T2 quantification at 7T with phase-cycled balanced steady-state free precession

Berk Can Acikgoz1,2,3, Cristina Sainz Martinez4,5, Adele L.C. Mackowiak1,2,6, Nils M.J. Plähn1,2,3, Yasaman Safarkhanlo2,3,7, Gabriele Bonanno1,8,9, Eva S. Peper1,2, João Jorge4,5, and Jessica A.M. Bastiaansen1,2
1Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, 2Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 3Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland, 4CSEM - Swiss Center for Electronics and Microtechnology, Bern, Switzerland, 5CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 6Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 7Department of Cardiology, Inselspital, University Hospital Bern, Bern, Switzerland, 8Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 9Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland

Synopsis

Keywords: Quantitative Imaging, Brain, Susceptibility, high-field, bSSFP

Motivation: Phase-cycled(PC) balanced steady-state free precession(bSSFP) sequences offer yet-to-be-explored capabilities for quantitative susceptibility mapping(QSM), T1, and T2 mapping, particularly attractive for 7T applications.

Goal(s): To determine the potential of PC-bSSFP for simultaneous QSM, T1 and T2 mapping in the brain at 7T.

Approach: PC-bSSFP-based off-resonance, tissue phase, T1 and T2 maps are compared with reference maps obtained from ME-GRE and MP2RAGE, in three subjects at 7T.

Results: PC-bSSFP-based off-resonance and tissue phase maps agreed with ME-GRE-based references with absolute mean errors of 13.2±3Hz and 8.9±3.7Hz, respectively. PC-bSSFP-based T1 and T2 maps matched the expected brain contrast with high precision.

Impact: At 7T, PC-bSSFP enables quantitative measurements of susceptibility, T1, and T2, within one acquisition, while providing high quality weighted images with a clear distinction between different brain structures.

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Abstract

Keywords