Keywords: Tumors (Post-Treatment), Arterial spin labelling, Brain Metastasis
Motivation: Brain metastases (BM) have increased frequency of treatment-related changes difficult to distinguish from progressive disease. To date, there are no studies evaluating arterial spin labeling (ASL) for BM patients during post-therapy follow-up.
Goal(s): To evaluate the feasibility of velocity-selective ASL (VSASL) derived cerebral blood flow (CBF) mapping in differentiating metastases recurrence from treatment-induced changes.
Approach: VSASL was applied to 9 BM patients, and compared with pseudo-continuous ASL (PCASL), dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI), and pathologic confirmation for some patients.
Results: VSASL is clinically feasible and more comparable with DSC-PWI than PCASL in patients with treated BM at suspicion of tumor progression.
Impact: This study showed that velocity-selective arterial spin labeling has the potential to offer a non-invasive alternative to dynamic susceptibility contrast perfusion-weighted imaging in differentiating tumor recurrence from treatment-induced changes among patients with brain metastases.
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