Keywords: Tumors (Pre-Treatment), Cancer, brain metastases, contrast clearance analysis (CCA)
Motivation: Differentiating tumour progression and treatment-induced changes in brain metastases is challenging, and quantitative measures of tumour burden and response are needed.
Goal(s): To develop and compare quantitative contrast clearance analysis (CCA) mapping techniques with conventional qualitative approaches in 9 patients with brain metastases.
Approach: We assessed the correlation of Relative Enhancement and Fractional Enhancement methods with conventional CCA in the brain and within detected tumour regions.
Results: Fractional Enhancement mapping was superior to relative enhancement in terms of its statistical properties and correlation with conventional CCA.
Impact: Quantitative enhancement fraction mapping of contrast clearance analysis (CCA) data is clinically feasible and demonstrates good correlation with conventional CCA. When used in combination with conventional radiological CCA, it may help quantify post-treatment changes in brain metastases following treatment.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords