Keywords: Tumors (Pre-Treatment), Brain Connectivity, H3K27M-altered diffuse midline glioma, structural covariance networks, graphy theory, topological properties
Motivation: H3K27M-altered diffuse midline glioma (DMG) is a highly infiltrative and deadly form of brain cancer with a dismal prognosis. The mechanisms underlying its aggressiveness remain elusive.
Goal(s): To elucidate alterations in whole-brain morphological networks in diffuse midline glioma patients and assess whether such alterations are associated with the H3K27M mutation.
Approach: A whole-brain structural covariance network (SCN) was constructed based on cortical thickness.
Results: The topological characteristics of structural covariance network (SCN) were severely disrupted in DMG. Additionally, H3K27M mutations may induce more aggressive whole-brain network damage.
Impact: The research offers novel insights into the mechanisms of progression in H3K27M-altered DMG, which may help in developing new treatment protocols.
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