Abstract #3847

The Value of CEST MRI of Peritumoral Regions in Post-Therapy Malignant Glioma Assessment

Qianqi Huang^1,2, Puyang Wang², Jingpu Wu^2,3, Mingchao Liu⁴, Yunfan Zou^2,5, Jinyuan Zhou², and Shanshan Jiang²

¹Department of Computer Science, Johns Hopkins University, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Data Science, Johns Hopkins University, Baltimore, MD, United States, ⁵Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Tumors (Post-Treatment), CEST & MT

Motivation: Monitoring post-chemoradiotherapy malignant gliomas is a persistent challenge in neuro-oncology. The peritumoral region, closely related to tumor recurrence, has been infrequently examined in the imaging pattens and the potential mechanism.

Goal(s): Our objective was to explore whether CEST MRI could distinguish tumor recurrence from treatment effects and uncover potential mechanisms behind high-grade gliomas' invasive behavior.

Approach: We investigated the CEST effects at 3.5ppm and 2.0ppm, as well as T1 and T2 values from the peritumoral regions of malignant gliomas with histogram analysis.

Results: Significant higher CEST effects across chemical shift offsets were presented in peritumoral regions in recurrent tumor compared with treatment effects.

Impact: The different progressive patterns in peritumoral regions between treatment effects and tumor recurrence are assessable by CEST MRI. It provides a potential imaging maker matrix to unveil the mechanism of invasive behavior of malignant gliomas.

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