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Abstract #3862

Quantification of BBB Permeability in glioma using ASL with tissue specific T2 values

Ayse Irem Cetin1, Gulce Turhan1, Beatriz E. Padrela2, Amnah Mahroo3, Simon Konstandin3, Daniel Christopher Hoinkiss3, Nora-Josefin Breutigam3, Vera Keil2, Ayca Ersan-Danyeli4,5, Koray Özduman5,6, Klaus Eickel3,7, Henk-Jan Mutsaerts2,8,9, Jan Petr10, Matthias Günther3,7,11, Alp Dincer5,12, and Esin Ozturk-Isik1,5
1Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Amsterdam University Medical Center, Amsterdam, Netherlands, 3Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, 4Department of Pathology, Acibadem University, Istanbul, Turkey, 5Brain Tumor Research Group, Acibadem University, Istanbul, Turkey, 6Department of Neurosurgery, Acibadem University, Istanbul, Turkey, 7mediri GmbH, Heidelberg, Germany, 8Radiology and Nuclear Medicin, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, 9Amsterdam Neuroscience, Brain Imaging, Amsterdam University Medical Center, Amsterdam, Netherlands, 10Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 11University of Bremen, Bremen, Germany, 12Department of Radiology, Acibadem University, Istanbul, Turkey

Synopsis

Keywords: Tumors (Pre-Treatment), Arterial spin labelling

Motivation: Blood brain barrier arterial spin labeling (BBB-ASL) could assess BBB integrity. However, the assumption of homogeneous T2 in data fitting might be broken in gliomas.

Goal(s): To evaluate the BBB integrity in gliomas with regional tissue-specific T2.

Approach: A mono-exponential T2 fitting was used to obtain tissue-specific T2 values to estimate time of water exchange (Tex) and perfusion (CBF) in the tumor, normal-appearing white (NAWM), and gray matter (NAGM) using ExploreASL.

Results: Higher Tex in NAWM, and lower Tex in the tumor and NAGM were observed and the tumor heterogeneity was better depicted when tissue-specific T2 values were used.

Impact: Water exchange and perfusion maps are highly affected by the tissue T2 value used in BBB-ASL data processing. Applying tissue-specific T2 correction has resulted in a more reliable evaluation of BBB integrity in gliomas.

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Abstract

Keywords