Keywords: Tumors (Pre-Treatment), Tumor, Glioma; Amide proton transfer imaging; apparent diffusion coefficient; Gene
Motivation: To the best of our knowledge, no study has explored the predictive ability of APT for ATRX mutations in gliomas.
Goal(s): Investigating APT and ADC's predictive capacities for ATRX mutations in WHO grade 2/3 gliomas with IDH mutations, we conducted a retrospective analysis.
Approach: We retrospectively analyzed data from these patients and extracted features for modeling.
Results: The results revealed the APT-median became the key diagnostic parameter, and the model developed showed the highest diagnostic efficiency. The histogram analysis method based on APT and ADC is an effective non-invasive tool for predicting ATRX gene status.
Impact: Our study, to our knowledge, pioneered the use of APT in predicting ATRX mutations in gliomas and established histogram analysis of APT and ADC as an effective non-invasive tool for ATRX gene prediction in IDH mutant WHO grade 2/3 gliomas.
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