Keywords: Aging, Aging, CEST, NOE
Motivation: Demyelination and lipid degeneration occurs as the human brain ages. Our motivation was to investigate the age-dependent variations of these lipids changes in subcortical gray matter regions using NOEMTR in the brains of 15 subjects.
Goal(s): To determine the correlation of the human brain NOEMTR metric with age.
Approach: We performed NOE MRI experiments on multiple subjects from ages (24Y-76Y) using NOEMTR at 3T.
Results: The Spearman’s correlation coefficient indicates that NOEMTR declines in several brain subregions with aging.
Impact: NOEMTR can be used to track lipid changes in white and gray matter subregions of the aging brain.
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