Keywords: Aging, Aging, thalamus
Motivation: Brain shrinkage does not happen to all areas uniformly and could be sex dependent.
Goal(s): We aimed to assess cross-sectionally the interactive effects of age and hypertension on the subcortical volumes and asymmetries in normal adult brains.
Approach: Brain structural images were acquired in 147 normal volunteers at a 3T scanner.
Results: All volumes demonstrated negative correlation with age but only the thalamic volume in both sexes, and the putamen volume in women reached the threshold of statistical significance of P=0.007. The thalamic asymmetry was the only measure that showed positive correlation to hypertension in women.
Impact: Among seven subcortical structures examined, the thalamic volume demonstrated a negative association with age in normal adult brains. Further research is needed to correlate this finding with cognition.
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