Abstract #3875

How much, and in which directions, do subjects move during MRI scans?

Kurt Schilling¹, Michael Kim², Muwei Li³, Yurui Gao¹, Derek Archer⁴, Chenyu Gao², Ema Topolnjak², Nazirah Mohd Khairi², Susan M Resnick⁵, Lori Beason-Held⁵, Adam Anderson², Sophia Vinci-Booher², Angela L Jefferson⁴, John C Gore², Bennett A Landman², The BIOCARD Study Team⁶, The Alzheimer’s Disease Neuroimaging Initiative (ADNI)⁷, and Aging Brain: Vasculature, Ischemia, and Behavior S (ABVIB)⁸

¹Vanderbilt University Medical Center, Nahville, TN, United States, ²Vanderbilt University, Nashville, TN, United States, ³Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Vanderbilt Memory and Alzheimer's Center, Nashville, TN, United States, ⁵Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States, ⁶The BIOCARD Study Team, Baltimore, MD, United States, ⁷The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Los Angeles, CA, United States, ⁸University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Aging, Brain, Motion, Artifacts, Diffusion

Motivation: Subject motion can cause artifacts in MR images and biases in subsequent quantification.

Goal(s): A thorough characterization of motion across multiple cohorts/consortiums has not been performed, particularly with diffusion MRI data.

Approach: We use diffusion MRI data from 14,440 subjects from 10 consortiums (aged 0-100) to characterize (1) how much subjects move during scanning; (2) what kind of head motion is most common; (3) whether motion increases as acquisition proceeds; (4) if motion is associated with age; or (5) with cognitive decline.

Results: Knowledge of the magnitude and direction of motion provides guidance for motion mitigation strategies and informed preprocessing strategies.

Impact: Subject motion induces artifacts and biases in MR images. Characterizing motion magnitude and directions, as well as motion correlates, informs and improves motion mitigation strategies and image processing pipelines.

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