Abstract #3877

Deciphering the Mediator Role of White Matter Function in Age-Related Cognitive Decline

Muwei Li^1,2, Kurt G Schilling^1,2, Fei Gao³, Lyuan Xu^1,4, Soyoung Choi^1,2, Yurui Gao^1,5, Zhongliang Zu^1,2, Adam W Anderson^1,5, Zhaohua Ding^1,4,5,6, Bennett A Landman^1,2,4,5, and John C Gore^1,2,5

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, ⁴Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, United States, ⁵Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁶Department of Computer Science, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Aging, Aging, fMRI, White matter, Resting state, Cognition

Motivation: Unraveling how age-related changes in brain structure and function affect cognitive functions.

Goal(s): To determine the mediation role of white matter functional metrics in cognitive decline with aging.

Approach: Employing fMRI, graph theory, and mediation analysis to assess how the effect of changes in WM BOLD activity with age influence or reflect cognitive performance.

Results: Identified significant white-matter mediators linking age to cognitive performance.

Impact: Contributes a fresh perspective to our understanding of the functional architecture of the aging brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.