Abstract #3884

Characterizing the age-related changes of hippocampal arterial transit time and perfusion across adult lifespan

Chenyang Li^1,2,3, Zhe Sun^1,2,3, Henry Rusinek^1,2, Jiangyang Zhang^1,2, Thomas Wisniewski⁴, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States, ⁴Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Perfusion, Aging brains

Motivation: Age-related changes of arterial transit time (ATT) and perfusion (CBF) measurement in hippocampus subfields is still under-investigated.

Goal(s): To quantitatively characterize the age-related hippocampal perfusion changes in a subfield-specific manner to better understand its involvement in neurodegenerative changes and dementia.

Approach: T1-weighted images and mbPCASL data from the Human Connectome Project-Aging (HCA) was analyzed to obtain subfield-specific measurements of ATT and CBF in hippocampus.

Results: The lowest perfusion measurement was observed in CA1 region across all age groups. Age trajectories of CBF and ATT were demonstrated in different subfields with female showing a more significant decrease of hippocampal perfusion.

Impact: Using Human Connectome Project–Aging (HCA) dataset, this study revealed age-related subfield-specific changes in hippocampal ATT and CBF across the adult normative lifespan, including subiculum, CA1-CA4 and the dentate gyrus.

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