Abstract #3887

Cognitive impairment is associated with elevated oxygen extraction and metabolism in the medial temporal lobe

Jie Song¹, Wen Shi¹, Kaisha Hazel², Ebony Jones², George Pottanat², Cuimei Xu², Julia Suconic³, Doris Lin², Paul Rosenberg⁴, Sevil Yasar⁵, Rita Kalyani⁶, Abhay Moghekar⁷, Marilyn Albert⁷, Hanzhang Lu², and Dengrong Jiang²

¹Department of Biomedical Engineering, Johns Hopkins University School of Engineering, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Aging, Neurodegeneration

Motivation: Currently, the primary MRI-based biomarker for cognitive dysfunction is the atrophy of medial-temporal-lobe (MTL). However, MTL atrophy represents a late stage of tissue damage. Functional biomarkers such as the MTL oxygen metabolism may be more sensitive in early stages.

Goal(s): To evaluate the association of MTL oxygen metabolism with cognitive function in non-demented elderly individuals.

Approach: We used a novel MRI technique to evaluate the MTL oxygen metabolism in 48 elderly subjects. Cognitive function of the participants was assessed.

Results: Worse cognitive scores were associated with elevated oxygen extraction and metabolic rate in the MTL, but not with the volume of MTL.

Impact: Our findings indicated that measuring the oxygen extraction and metabolic rate in the medial temporal lobe may be more sensitive than structural atrophy in detecting tissue damage in early stages of cognitive impairment.

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