Abstract #3888
ASL-derived cerebrovascular brain-age improves associations with cognitive decline
Mathijs B.J. Dijsselhof1,2, Floor H. Duits3,4,5, Wibeke Nordhøy6, Dani Beck7,8,9, Lars T. Westlye7,8,10, James H. Cole11,12, Wiesje M. Van der Flier3,4,13, Frederik Barkhof1,2,14, Jan Petr1,15, and Henk J.M.M. Mutsaerts1,2
1Radiology & Nuclear Medicine,Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands, 2Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands, 3Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, 4Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands, 5Neurochemistry lab, Department of Clinical Chemistry, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, Netherlands, 6Department of Physics and Computational Radiology, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 7Norwegian Centre for Mental Disorders Research (NORMENT), Oslo University Hospital, Oslo, Norway, 8Department of Psychology, University of Oslo, Oslo, Norway, 9Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway, 10KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway, 11Dementia Research Centre, Queen Square Institute of Neurology, UCL, London, United Kingdom, 12Centre for Medical Imaging Computing, Computer Science, UCL, London, United Kingdom, 13Epidemiology and Data Science, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands, 14Queen Square Institute of Neurology and Centre for Medical Image Computing, UCL, London, United Kingdom, 15Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany
Synopsis
Keywords: Aging, Aging
Motivation: Structural brain ageing models are associated with cognitive decline, and the addition of arterial spin labelling (ASL)-derived improved brain-age estimation accuracy, but the relation between cerebrovascular ageing and cognitive decline is not yet fully understood.
Goal(s): To assess the contribution of ASL in the relationship between brain-age estimates and cognitive decline.
Approach: Brain-age estimation accuracy and linear relationships with composite cognitive scores were compared between structural-only (T1w and FLAIR), ASL-only, and structural+ASL models.
Results: Combined structural and ASL brain-age models showed the highest accuracy and increased effect sizes with composite cognitive scores, however, ASL-only models showed unexpected relationships.
Impact: Combined structural-ASL brain-age models might present a surrogate biomarker in an earlier stage of cognitive decline, aiding in diagnosis and treatment monitoring. Possible mediation effects of ASL on the association of structural decline with cognitive domains should be investigated further.
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