(ISMRM 2024) 3D pCASL with dual PLDs could reflect cerebral blood flow regulation in patients with hydrocephalus
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Abstract #3894

3D pCASL with dual PLDs could reflect cerebral blood flow regulation in patients with hydrocephalus

Yawen Xiao1, Shiqi Chen1, Jiankun Dai2, and Xinlan Xiao1
1The Second Affiliated Hospital of Nanchang University, Nanchang, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Other Neurodegeneration, Arterial spin labelling, Hydrocephalus, cerebral blood flow, cerebral blood flow regulation, hemodynamics

Motivation: It is unclear whether the 3D pCASL with dual PLDs can reflect blood flow (CBF) regulation in hydrocephalus patients.

Goal(s): To investigate hemodynamic characteristics in patients with hydrocephalus and whether ΔCBF can reflect cerebral regulation.

Approach: Patients with hydrocephalus and control subjects were retrospectively included. Regional CBF and ΔCBF were compared using covariance analyses. The relationship between ΔCBF and ventricular dilatation degree was investigated using linear regression analyses and interaction analysis.

Results: Compared to the control group, hydrocephalus patients showed larger ΔCBF in all brain regions except for the bilateral parietal cortex and cerebellum.

Impact: Patients with hydrocephalus initiate cerebral regulation to maintain CBF but require longer arterial transit times. The ability to regulate CBF in brain regions represented by the watershed is associated with the degree of ventricular dilation.

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Keywords

hydrocephaluspatientscortexwatershedcerebralflowobstructivecommunicatingregulationbloodventricular