Abstract #3907

In vivo microstructural mapping of the hippocampus in older adults with familial risk for Alzheimer’s disease

Alfie Wearn¹, Stéfanie A. Tremblay^2,3, Ilana R. Leppert⁴, Giulia Baracchini¹, Colleen Hughes¹, Gary R. Turner⁵, Claudine Gauthier^2,3, Christine L. Tardif^1,6,7, and R. Nathan Spreng^1,6,8,9

¹Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ²Department of Physics, Concordia University, Montreal, QC, Canada, ³Montreal Heart Institute, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Department of Psychology, York University, Toronto, ON, Canada, ⁶McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada, ⁷Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, ⁸Douglas Mental Health University Institute, Montreal, QC, Canada, ⁹Departments of Psychology and Psychiatry, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Alzheimer's Disease, Quantitative Imaging, Hippocampus, Microstructure

Motivation: Understanding prodromal Alzheimer’s disease is essential for treatment development. Hippocampal volume loss indicates significant atrophy and may occur too late to slow disease progression.

Goal(s): We aimed to precisely map spatial variation in hippocampal microstructure in vivo using quantitative MRI in prodromal AD.

Approach: We use multiparametric quantitative MRI to comprehensively map hippocampal microstructure in healthy older adults with first-degree family history of Alzheimer’s disease and correlate maps with demographic risk factors for Alzheimer's disease.

Results: We identified two key contributors of microstructural variation (myelin content and free water). We revealed localized age-related demyelination and sex differences in hippocampal proton density.

Impact: This research provides crucial insights into age-related hippocampal microstructural changes and their implications for Alzheimer's disease. It has the potential to advance early detection and intervention strategies, ultimately improving patient outcomes in Alzheimer's disease management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.