Abstract #3928

Translating a Non-invasive Hybrid PET/MR Method of Imaging Cerebral Oxygen Metabolism to Humans

Graham Deller^1,2, Linshan Liu², Justin Hicks^1,2, Lucas Narciso³, Felix Wehrli⁴, and Keith St. Lawrence^1,2

¹University of Western Ontario, London, ON, Canada, ²Lawson Health Research Institute, London, ON, Canada, ³Centre for Addiction and Mental Health, Toronto, ON, Canada, ⁴University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: PET/MR, Arterial spin labelling, Cerebral Oxygen Metabolism

Motivation: To develop a non-invasive method of imaging CMRO₂ by hybrid PET/MRI.

Goal(s): Translate a previously validated PET/MR technique capable of imaging CBF, OEF, and CMRO₂ to human studies.

Approach: Technique combines [¹⁵O]O₂-PET with MRI measurements of whole-brain CMRO₂ and arterial spin labeling images of CBF.

Results: Good agreement to literature regional CMRO₂ values.

Impact: Hybrid PET/MRI can simplify the PET-only technique of measuring regional CMRO₂ by avoiding arterial sampling and only requiring one radiotracer, which reduces scan time and radiation dose, while enabling simultaneous acquisition of perfusion and tissue oxygen extraction.

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