Keywords: Biology, Models, Methods, Bladder, Uro-dynamic MRI
Motivation: Recently developed MRI-Urodynamics methods require rigorous validation. In vitro approaches have been implemented, however lack of tissue-like mechanical properties of the in models limits their applicability.
Goal(s): Develop and implement an ex-vivo bladder model for validation of MRI-Urodynamics.
Approach: Porcine bladder was obtained and connected to a syringe pump to conduct MRI experiments during filling and voiding at various flow-rates. Simultaneous pressure measurements were performed during MRI.
Results: Ex-vivo bladder MRI experiments were successfully conducted. MRI-derived flow-rates agree within 10% when compared to the flow-rates imposed by the syringe pump. Pressure-volume analysis provided means of comparison of bladder performance between filling and voiding.
Impact: 3D dynamic MRI can assess anatomical changes in the bladder during voiding and filling. Systematic validation of this technique can enhance its clinical use.
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