Keywords: Biology, Models, Methods, Diffusion Tensor Imaging, Cardiovascular
Motivation: Changes in myocardial microstructure that underlie post-myocardial infarction (MI) left ventricular (LV) remodelling may contribute to progressive deterioration in cardiac function and increased risk of adverse clinical events.
Goal(s): To assess post-MI temporal alterations of myocardial microstructure.
Approach: A longitudinal Diffusion Tensor CMR (DT-CMR) pre-clinical study was performed, including healthy, 3 days and 4 months post-MI timepoints, followed by ex-vivo imaging at low and high spatial resolution.
Results: High-resolution ex-vivo DT-CMR suggests preserved helical structure within the infarct core in this swine MI model, with endocardial layers appearing more compressed than mid and epicardial layers.
Impact: Improved understanding of temporal alteration of myocardial microstructure and its dynamics post-MI as seen by in-vivo DT-CMR may facilitate diagnosis and prognostication after MI.
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