Keywords: Probes & Targets, Preclinical
Motivation: Early diagnosis of transplant rejection can help to improve the immune-related management of transplant recipients.
Goal(s): Developing the new methods for early and non-invasive diagnosis of acute cellular rejection to unmet clinical needs.
Approach: Develop a PET/MRI dual-model granzyme B (GzmB) targeted probe for non-invasively detection of transplant acute cellular rejection.
Results: In preclinical heart graft models of rejection, our PET/MRI dual-model GzmB targeted probe allow noninvasive discrimination of early acute cellular rejection mediated by recipient cytotoxic CD8+ T cells.
Impact: In the future, this technology developed a PET/MRI dual-model probe for imaging GzmB produced by cytotoxic CD8+ T cells, enabling early non-invasive diagnosis of allograft rejection with high sensitivity and high spatial resolution.
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