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Abstract #3959

Physiological and macropathological results in swine model at 123 MHz in experimental setup for investigating thresholds of tissue damage

Chie-Hee Cho1,2 and Lutz Lüdemann2,3
1Institute for diagnostic and interventional Radiology, University Clinic Jena, Jena, Germany, 2Department of Radiotherapy, Charite Universitätsmedizin Berlin, Berlin, Germany, 3Department of Radiotherapy, Medical Physics Section, University Hospital Essen, Essen, Germany

Synopsis

Keywords: Large Animals, Nonhuman Primates, Safety, Swine, thermoregulation, temperature curves

Motivation:
Radiofrequency used during MRI exams heat tissue. The temperature increase is unknown and the thermoregulatory responses still need to be analyzed.

Goal(s): To analyse the temperatures within the thresholds. Are any changes seen. Is the biological simulation replicable in living swine.

Approach: SAR levels in the 2.mode were planned in the swine as an animal model.

Results: The thermoregulatory model (temperature going into a plateau) is only one pattern next to 3 other patterns (linear, parabolic, and sinusoidal). So these will change the calculations of simulations for temperatures in humans receiving MRI exams.

Impact: Radiofrequency induced temperature changes in MRI exams need to be reevaluated as new thermoregulatory patterns are observed. Increased internal temperatures are subconsciously discerned causing thermoregulation to avoid tissue damage.

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