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Abstract #3971

Perfluorocarbon-PLGA particle ultrastructure affects pH sensitivity in 19F NMR and MRI

Alvja Mali1,2, Paul White3, Nicolas Stumpe4, Koen van Riessen5, Cyril Cadiou6, Françoise Chuburu6, and Mangala Srinivas7
1Wageningen University and Research, Wageningen, Netherlands, 2Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, 3Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands, Nijmegen, Netherlands, 4Institute for Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany, Dusseldorf, Netherlands, 5Department of Cell Biology and Immunology, Wageningen University and Research, Wageningen, The Netherlands, Wageningen, Netherlands, 6ICMR Equipe Chimie de Coordination, Universite de Reims, Reims, France, 7Wageningen university and research, Wageningen, Netherlands

Synopsis

Keywords: Probes & Targets, Contrast Agent

Motivation: We aim to advance biocompatible 19F-MR contrast agent to enhance imaging diagnostic in cancer.

Goal(s): Nanoparticles (NPs) internal structure impacting Gd-enhanced effect on 19F-MR signal strength, relaxation times and pH-sensitivity.

Approach: Systematic investigation using 1H/19F-MR to understand how NPs structure affects the interaction between co-encapsulated Gd and 19F and focusing on multi-core NPs and their acidic pH-sensitivity on 19F-MR relaxation times.

Results: Our study revealed that 19F-MR signal strength is pH-dependant. After cellular uptake, multi-core NPs co-encapsulating Gd and PFCE exhibited higher T2 values and stronger signal, influenced by lysosomal acidity, highlighting pH role in MR signal modulation.

Impact: The pH-sensitive 19F-MR probe enhance NPs tracking after cell internalization and by that it holds great promise for tissue pathology imaging, as cancer diagnostics.

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Abstract

Keywords