Keywords: Cancer, Tumor, colorectal cancer; microsatellite instability,DCE-MR, perfusion parameters,ADC
Motivation: To find an imaging method that can evaluate microsatellite status of colorectal cancer (CRC).
Goal(s): To investigate the value of DCE-MR perfusion parameters and ADC in predicting microsatellite instability of CRC.
Approach: DCE-MR perfusion parameters, including Ktrans, Ve, kep, iAUC and ADC were compared between microsatellite instability (MSI) and microsatellite stability (MSS) CRC groups. Receiver operating characteristics (ROC) curve was drawn to evaluate diagnostic efficacy.
Results: Univariable analysis revealed that kep had highest diagnostic accuracy (AUC, 0.890; sensitivity, 76.4%; specificity, 90.9%). The diagnostic accuracy of kep combined ADC was the greatest in multivariable analysis (AUC, 0.970; sensitivity, 90.0%; specificity, 100%).
Impact: The combination of DCE-MRI based kep value and DWI based ADC value can provide excellent diagnostic accuracy in non-invasively predicting microsatellite status. This study provides insight into potential application of multi-modality MRI in predicting patient with CRC.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords