Keywords: Treatment Response, Diffusion/other diffusion imaging techniques, Rectal Cancer
Motivation: Rectal cancer response assessment utilizes primarily T2 weighted and diffusion MRI. Reduced field of view diffusion has been shown to have higher imaqe quality and resolution than traditional EPI-based diffusion.
Goal(s): We compare reduced field of view diffusion to mrTRG and sigmoidoscopy for assessment of clinical response.
Approach: 32 patient MRI were evaluated after treatment with short course radiation (30 Gy, 5 fractions), and FOLFOXIRI and assessed with mrTRG system, ADC on reduced field of view DWI, and sigmoidoscopy.
Results: Reduced field of view diffusion is highly accurate for assessment of clinical response nearly matching the performance of mrTRG and surpassing sigmoidoscopy.
Impact: Reduced field of view diffusion should be considered for use in clinical protocols assessing rectal cancer treatment response along with T2 weighted MRI and clinical assessment.
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