Keywords: Pancreas, Hyperpolarized MR (Non-Gas), Pancreatic Cancer, Metabolic Imaging, Early Detection
Motivation: There is an unmet need for early diagnosis of pancreatic cancer due to the asymptomatic nature of the disease.
Goal(s): The goal is to detect the early stages of pancreatic cancer by monitoring the altered metabolism in premalignant pancreatic lesions in vivo with hyperpolarized metabolic imaging.
Approach: This is validated in two mechanistic pathways of cancer progression, (1) pancreatic intraepithelial neoplasia (PanIN), and (2) intraductal papillary mucinous neoplasm (IPMN).
Results: Increased lactate flux is observed with progression of the premalignant lesions in both the pathways. No increase in lactate flux is observed in pancreatitis, a known confounder demonstrating the specificity of this technique.
Impact: This research described has the potential for leading to practice-changing recommendations for non-invasively detecting and monitoring premalignant lesions and incipient pancreatic cancer, to prevent over-diagnosis and over-treatment of cysts that harbor indolent biology.
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