Abstract #4004

Investigation of clinical applicability of multi-parametric 4D-MRI for radiotherapy in liver cancer

Sha Li^1,2, Xianggao Zhu², Chen Zhang³, Tian Li⁴, and Yanye Lu¹

¹Institute of Medical Technology, Peking University Health Science Center, Beijing, China, ²Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education / Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing Cancer Hospital & Institute, Beijing, China, ³MR Scientific Marketing, Digital Imaging, Siemens Healthineers Ltd, Beijing,China, Beijing, China, ⁴Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, Hong Kong, China

Synopsis

Keywords: Cancer, Cancer

Motivation: Although many methods for generating 4D-MRI have been studied, there are few clinical applications for radiotherapy based on 4D-MRI.

Goal(s): To investigate the clinical potential of multi-parametric 4D-MRI in liver cancer radiotherapy.

Approach: Target contours were delineated on the planning CT with assisted by 3D-MRI and multi-parametric 4D-MRI. Clinical plans were designed based on these contours respectively. Target volume and contours in three different hepatic lobes and target dose were compared and evaluated.

Results: 3D image-guided target delineation may be more likely to underestimate target volume and compromise dose coverage.

Impact: Multi-parametric 4D-MRI can be applied in clinical radiotherapy, which provides more accurate target delineation and dose coverage.

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