Abstract #4010

Value of sarcopenia as an imaging biomarker in patients with primary sclerosing cholangitis (PSC)

Kristina Imeen Ringe¹, Alena Levers¹, Judith Pantke¹, Henrike Lenzen², Daniel Düx¹, Filip Klimes¹, Richard Taubert², Hans-Heinrich Wedemeyer², and Frank Wacker¹

¹Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Gastroenterlogy, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany

Synopsis

Keywords: Liver, Liver

Motivation: Sarcopenia has been associated with a higher risk of adverse outcomes in patients with chronic diseases.

Goal(s): To evaluate sarcopenia as a prognostic biomarker in patients with primary sclerosing cholangitis (PSC).

Approach: Muscle mass was measured in 231 PSC patients at the level of L3 and correlated with patient demographics, clinical scores and clinical endpoints.

Results: Sarcopenia was more prevalent in women and in patients without concomitant inflammatory bowel disease. Muscle mass significantly correlated negatively with the MELD score, but not with solid clinical endpoints.

Impact: While sarcopenia is highly prevalent in PSC patients, imaging-based quantification of muscle mass seems to be of limited prognostic value.

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