Abstract #4011

Non-contrast Portal Venous 4D Flow MRI in an Obese Cohort Undergoing Weight Loss Surgery: Feasibility and Correlations with BMI and MASH

Raphael do Vale Souza¹, Thekla H. Oechtering¹, Alma Spahic², David T. Harris¹, Tanya Wolfson³, Kevin M. Johnson⁴, Danielle Batakis³, Michael S. Middleton³, Alejandro Roldan-Alzate⁴, Gavin Hamilton³, James A. Goodman⁵, Lael Ceriani³, Rashmi Agni ⁴, Anne Lidor⁴, Luke Funk⁴, Oliver Wieben⁴, Claude B. Sirlin ³, and Scott B. Reeder ¹

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³University of California San Diego, San Diego, CA, United States, ⁴University of Wisconsin-Madison, Madison, WI, United States, ⁵Pfizer, Cambridge, MA, United States

Synopsis

Keywords: Liver, Velocity & Flow

Motivation: To evaluate the potential of portal flow as a biomarker of metabolic-dysfunction associated steatohepatitis (MASH) in obese patients undergoing weight loss surgery (WLS).

Goal(s): Determine feasibility of portal non-contrast 4D Flow in obese patients, to assess whether flow is impacted by BMI and the presence of MASH.

Approach: Portal flow was quantified at 5 timepoints before and after WLS. Mass conservation and inter-observer agreement assessed validation. Results were correlated with BMI and presence/absence of biopsy-proven MASH.

Results: Non-contrast 4D Flow was successful in 339/382 exams (87%); BMI correlated with portal flow (p=0.010); flow was significantly higher in MASH (p=0.013, AUC=0.706)

Impact: Our work demonstrates the feasibility of non-contrast 4D flow in individuals with obesity. Further, it indicates possible effects of obesity on portal venous flow and demonstrates its potential as a treatment monitoring tool in MASH.

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