Abstract #4023

Free-breathing simultaneous quantification of fat fraction, R2*, and T1 at 0.55T: Validation in a clinical cohort

Michael Ohliger¹, Isabelle Remick¹, Cheng Hong¹, Thomas Hope¹, Jingjia Chen², Daniel K Sodickson², Hersh Chandarana², Zhitao Li³, Li Feng², and Yang Yang¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Synopsis

Keywords: Liver, Low-Field MRI

Motivation: Improve accessibility of MRI by measuring quantitative liver biomarkers at 0.55T.

Goal(s): Perform and validate free-breathing radial stack-of-stars for simultaneous measurement of liver fat fraction, R2*, and T1 on a 0.55T system in patients with chronic liver disease.

Approach: 11 subjects undergoing 3T MRI were offered a 0.55T examination. Fat fraction and R2* were compared at both field strengths. Composite T1 was compared to water-only T1.

Results: Fat fraction at 0.55T was highly correlated to 3T, with minimal bias and variance. R2* correlation did not achieve statistical significance. Composite T1 was linearly related to water-only T1.

Impact: Free-breathing simultaneous measurement of important liver biomarkers is achievable in a low-cost commercially available MRI system, which promises to help make the benefits of MRI more accessible to patients who need it.

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