Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: The TauPS2APP mouse is a well-established model of Alzheimer’s Disease. Traditionally, analyses focus on hippocampus and isocortex, but brain-wide analysis may yield a more comprehensive description of brain degeneration and identify additional regional biomarkers.
Goal(s): Identifying robust signatures of brain degeneration resulting from amyloidosis and tauopathy
Approach: We conducted a brain-wide voxel-based analysis of longitudinal MRI data from TauPS2APP mice collected from three studies (n=123).
Results: We found expected and persistent hippocampal and isocortical volume differences between wildtype and TauPS2APP mice. Also, we identified progressive atrophy in caudoputamen (95% of 123 TauPS2APP mice) and expansion in subiculum/hippocampal commissures (89% of 123 mice).
Impact: We identified novel and robust regional biomarkers of progressive brain degeneration in the TauPS2APP mouse model of AD. These regions are additional targets for assessing brain degeneration associated with amyloidosis and tauopathy, and for testing new therapies.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords