Abstract #4040

CSF Mimicking Phantom based Evaluation of CSF Flow using Phase Contrast and Diffusion Imaging on a Highly Efficient Head Only Gradient System

Brock Jolicoeur¹, James Rice², Leonardo Rivera-Rivera³, Alejandro Rold Roldán-Alzate⁴, and Kevin Johnson⁵

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Medical Physics, Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁴Mechanical Engineering, Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medical Physics, Radiology, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Alzheimer's Disease, Velocity & Flow, cerebrospinal fluid, low-venc

Motivation: Accurate characterization of CSF flow dynamics is necessary for understanding of brain metabolite clearance pathways.

Goal(s): To compare PC and DWI techniques for slow CSF flow velocity at 3T in a clinical scanner and a heald-only high performance gradient system using high fidelity ventricle phantoms.

Approach: Flow pump experiments were performed on silicone phantom at each of the scanners using varying Vencs.

Results: Greater velocity-to-noise ratio (VNR) gains and diffusion sensitivity were observed from scans collected on the high performance gradient system

Impact: Generating physiologically realistic cerebral ventricles phantom and leveraging high performance gradient systems can enable low CSF flow assessment for studying brain waste clearance pathways.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.